研究業績

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学会(国際、国内)

国際学会、シンポジウム等招待講演

2019年度

  • Motohashi S : NKT cell-targeted immunotherapy for non-small cell lung cancer. 2019 Forum for TMU Research Center for Cell Therapy and Regeneration Medicine(CCTRM), 4/12/2019, Taipei/Taiwan

2018年度

  • Kobayashi N, Kuroda M, Yokote K, Saito Y, Aso M : Genetically Modified Adipocytes, GMAC, for Regenerative Cell Medicine and Gene Therapy. 5th International Symposium for Medicinal Sciences(第5回国際創薬シンポジウム), 3/22/2019 千葉
  • Hanaoka H, Yamaguchi M, Kgayama Y, Motohashi S, Fujiwara T : ARO activities in Japan and drug development. REACTA 2018 - Regional Asian Clinical Trial Annual Forum, 11/9-11/11/2018, Taipei/Taiwan
  • Tomohisa Iinuma, Daiju Sakurai, Yoshitaka Okamoto : The pathogenicity of memory Th2 cell is involved in the onset of allergic rhinitis and changed by immunotherapy. The Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology, 10/2018, Bangkok/Thailand
  • Kuroda M, Ishikawa K, Kubota Y, Mitsukawa N, Tawada A, Aoyagi Y, Asada S, Yamamoto T, Konno S, Tanaka S, Tanio M, Aso M, Saito Y, Wada J. Yokote K : First in human clinical trial of treatment of familial LCAT deficiency syndrome by self-transplantation of therapeutic-enzyme secreting adipocytes. 25th TERMIS (Tissue Engineering and Regenerative Medicine International Society) World Congress, 9/4-9/7/2018, 京都
  • Aoyagi Y, Kuroda M, Asada S, Onitake A, Kirinashizawa M, Yamamoto T, Tanaka S, Konno S, Tanio M, Saito Y, Yokote K, Aso M :  A novel technology for lifelong treatment of intractable plasma protein deficiency: Ex vivo-manipulated adipocytes for sustained secretion of therapeutic proteins. 25th TERMIS (Tissue Engineering and Regenerative Medicine International Society) World Congress, 9/4-9/7/2018, 京都
  • Ikari N, Kawashima T, Kubota Y, Motohashi S, Shimojo N, and Tsuji NM : Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 Immunity via Interferon-β from Human Dendritic Cells. International Symposium of International Scientific Association for Probiotics and Prebiotics 2018, 6/5-6/6/2018, Singapore
  • Tomohisa Iinuma, Fumie Ihara, Daiju Sakurai, Syuji Yonekura, Yoshitaka Okamoto : Memory T cell function in the onset of Allergic Rhinitis and the effect of Immunotherapy. 2018 European Academy of Allergy and Clinical Immunology Annual Congress, 5/2018, Munich/Germany
  • Tomohisa Iinuma, Daiju Sakurai, Yoshitaka Okamoto : The onset of Allergic Rhinitis is affected by additional function of memory T cell. The 17th Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery, 4/2018, Gwangju/Korea

2017年度

  • Negawa M, Ihara F, Kamata T, Takami M, Motohashi S : A role for immune checkpoint inhibitors in iNKT cell-based immunotherapy. The 2nd Chiba University – UC San Diego Symposium, 3/28/2018, Chiba
  • Motohashi S : NKT cell-targeted immunotherapy for non-small cell lung cancer. CD1-MR1 2017, 11/6/2017, Napa/USA
  • Ihara F, Sakurai D, Takami M, Okamoto Y, Motohashi S : Regulatory T cells increased in advanced head and neck cancer patients suppress NKT cell function and correlate with disease progression. CD1-MR1 2017, 11/6/2017, Napa/USA
  • Takami M, Ihara F, Kamata T, Motohashi S: A role of AhR signaling in NKT cell immunotherapy. CD1-MR1 2017, 11/6/2017, Napa/USA

2016年度

  • Kuroda M, Bujo H, Yokote K, Saito Y, Aso M : Ex Vivo Gene-manipulated Mature Adipocytes: Novel Gene Therapy Medicine for Sustained Protein Replacement Therapy of Variety of Intractable Diseases. 3rd International Symposium for Medicinal Sciences(第3回国際創薬シンポジウム), 3/26/2017 仙台

 2015年度

  • Tateno K, Takahara Y, Fujimoto Y, Hasegawa H, Nagai T, Kobayashi Y : Therapeutic Angiogenesis by Peripheral Blood Mononuclear cells and its Rationale for Designing a New Trial. Arteriosclerosis, Thrombosis, and Vascular Biology Peripheral Vascular Disease 2016 Scientific Sessions, Nashville, Tennessee, 2016/5/5-7
  • Motohashi S, and Mise N : Antibody-Dependent Cellular Cytotoxicity Toward Neuroblastoma Enhanced by Activated iNKT Cells. CD1-MR1 2015, 11/15/2015, Lorne/Australia
  • Tateno K, Takeda Y, Kobayashi Y : High MCV and Low Platelet Count Indicate Higher Risk to Develop Cardiovascular Events in Patients Undergoing Hemodialysis American Heart Association Scientific Sessions. Orlando, FL USA, 2015/11/7-11
  • Ihara F, Sakurai D, Motohashi S, and Okamoto Y : Analysis of regulatory T cells in peripheral blood of the patients with Head and Neck cancer and their inhibitory role on NKT cells. International Conference of Cancer Immunotherapy and Macrophages 2015, 7/9/2015, Tokyo
  • Kunii N, Makita Y, Ihara F, Uchida R, Fujikawa A, Motohashi S, Nakayama T, and Okamoto Y : Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T Cells Targeted to Salivary Gland Tumor. International Conference of Cancer Immunotherapy and Macrophages 2015, 7/9/2015, Tokyo
  • Kamata T, Suzuki A, Makita Y, Kunii N, Nakayama T, and Motohashi S : Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells. International Conference of Cancer Immunotherapy and Macrophages 2015, 7/9-11/2015, Tokyo

2014年度

  • Aso M, Kuroda M, Asada S, Aoyagi Y, Onitake A, Tanaka S, Konno S, Tanio M, Bujo H, Saito Y, and Yokote K : Novel ex vivo gene manipulation technology of mature adipocytes for sustained protein replacement therapy of variety of intractable diseases. The XXIInd Annual ESCGT Congress in collaboration with the NVGCT. 2014/ 10 ハーグ(オランダ).
  • Kuroda M, Aoyagi Y, Asada S, Aso M, Bujo H, Saito Y, and Yokote K : Development of ex vivo gene therapy for familial LCAT deficiency syndrome by self-transplantation of therapeutic-enzyme secreting adipocytes. The XXIInd Annual ESCGT Congress in collaboration with the NVGCT. 2014/10 ハーグ(オランダ).
  • Aoyagi Y, Kuroda M, Asada S, Aso M, Yokote K, Saito Y, and Bujo H : Treatment of familial LCAT deficiency syndrome by self-transplantation of therapeutic-enzyme secreting adipocytes. The 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress. 2014/9 京都.
  • Kuroda M, Holleboom AG, Stroes E, Asada S, Aoyagi Y, Kamata K, Yamashita S, Ishibashi S, Saito Y, Bujo H : Lipoprotein subfractions highly associated with renal damage in familial LCAT deficiency. The 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress. 2014/9 京都.
  • Kuroda M, Yokote K, Bujo H, Asada S, Aoyagi Y, Aso M, and Saito Y : Translational clinical research for treatment of familial LCAT deficient patients through transplantation of ex vivo gene-transduced autologous adipocytes. The 18th International Vascular Biology Meeting. 2014/4 京都.

2013年度

  • Motohashi S : NKT cell-targeting therapy for lung cancer and head and neck cancer. 7th International symposium on CD1 and NKT cells. Tour, France, 2013/9/13-17

2012年度

  • Ito T. and Minamino T : CDC42 and NFκB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells. Keystone Symposia on Molecular Basis of Vascular Inflammation and Atherosclerosis. Montana, USA, 2012/3/25-30
  • Ito T. and Minamino T : CDC42 and NFκB signaling contribute to pro-inflammatory phenotype of senescent endothelial cells. The 41st annual American Aging Association meeting. Texus, USA, 2012/6/1-5
  • Shimizu I, Yoshida Y, Katsuno T, Kobayashi Y, and Minamino T : Inhibition of adipose inflammation as a novel therapeutic target for heart failure. Basic Cardiovascular Sciences 2012 Scientific sessions. New Orleans, LA, U.S.A, 2012/7/23-26
  • Yoshida Y. and Minamino T: Notch signaling negatively regulates vascular endothelial cell senescence. Basic Cardiovascular Sciences 2012 Scientific sessions. New Orleans, LA, U.S.A, 2012/7/23-26
  • Nagato K, Motohashi S, Nakayama T : Accumulation of activated invariant NKT cells in the tumor microenvironment after α-galactosylceramide-pulsed antigen presenting cells. Clinical Immunology Society (CIS) Annual Meeting. Chicago, USA, 2012/5/17-20

2011年度

  • Kuroda M, Asada S, Aoyagi Y, Tanaka S, Konno S, Tanio M, Aso M, Saito Y, and Bujo H : Proliferative Adipocytes as Therapeutic Gene Vehicle toward Sustained Protein Replacement Therapy. "The American Society of Gene & Cell Therapy (ASGCT) 14th Annual Meeting", 2011/05/18-21

2010年度

  • Bujo H : Novel gene therapy using the autologous preadipocyte transplantation for the patients with LCAT deficiency. Amsterdam University Academic Medical Center (AMC) Vascular Medicine Symposium. Special lecture.
  • Bujo H : LR11, a novel biomarker for cardiovascular diseases. Amsterdam University Academic Medical Center (AMC) Vascular Medicine Symposium. Special lecture.
  • Bujo H : Dyslipidemia and cardiovascular disease. Vietnam Nutrition Association The 5th National Nutrition Scientific Conference. Invited lecture.
  • Bujo H : Dyslipidemia and cardiovascular disease. Ho Chi Minh City University of Medicine and Pharmacy Topic Course on dyslipidemia and diabetes. Invited lecture.
  • Minamino T : Cellular aging and lifestyle-related disease. 7th Japanese-German Frontiers of Science Symposium. Potsdam, Germany, 2010/11/11-14.
  • Taniguchi M, fujii S, Motohashi S, Nakayama T : NKT cell-targeted adjuvant cell therapy-from basic to clinic. 14th International Congress of Immunology. Kobe, Japan, 2010/08/22-27
  • Minamino T : Vascular aging and vascular injury: synonymous or analogous? 20th World Congress of the International Society of Heart Research. Kyoto, Japan, 2010/5/13-16.

2009年度

  • Minamino T : Aging signals involved in glucose homeostasis. JST Danish-Japanese Workshop "Molecular Diabetology". Copenhagen, Denmark, 2010/03/23-24.
  • Minamino T : Life style-related disease and cellular aging signal network. 2009 AVDRC International Symposium. Daegu, Korea, 2009/09/17.
  • Minamino T : Role of p53 in heart failure. 17th Asian Pacific Congress of Cardiology Symposium. Kyoto, Japan, 2009/5/20-23.

2008年度

  • Nakayama T : Combination therapy of In vitro expanded natural killer T cells and αGalactosylCeramide pulsed APCs in patients with recurrent head and neck carcinoma. The Second International Cell Therapy Conference Present and Future of Cell Therapy, Seoul, Korea 2008/11/20
  • Minamino T : Role of Cellular Aging in Cardiovascular Disease the Annual Spring Scientific Conference of the Korean Society of Lipidology and Atherosclerosis Symposium. Busan, Korea, 2008/5/18.

国内学会、シンポジウム等招待講演

2019年度

2018年度

2017年度

2016年度

2015年度

2014年度

2013年度

2012年度

2011年度

2010年度

2009年度

2008年度