千葉大学病院
未来開拓センター
Aso M, Yamamoto TT, Kuroda M, Wada J, Kubota Y, Ishikawa K, Maezawa Y, Teramoto N, Tawada A, Asada S, Aoyagi Y, Kirinashizawa M, Onitake A, Matsumura Y, Yasunaga K, Konno S, Nishino K, Yamamoto M, Miyoshi J, Kobayashi N, Tanio M, Ikeuchi T, Igari H, Mitsukawa N, Hanaoka H, Yokote K, Saito Y.(2022) First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency. Heliyon, 2022 e11271 DOI:10.1016/j.heliyon.2022.e11271
Kuroda M, Hori M, Maezawa Y, Kubota Y, Mitsukawa N, Shiko Y, Ozawa Y, Kawasaki Y, Saito Y, Hanaoka H, Yokote K. LCAT-trial-24 weeks: Protocol for a clinical study to evaluate the safety of regenerative medicine and gene therapy by the autologous transplantation of human lecithin:cholesterol acyltransferase gene-transduced human pre-adipocytes. Contemp Clin Trials Commun. 2022 Jun 9;28:100946. DOI:
10.1016/j.conctc.2022.100946Masuda T, Fujimoto H, Teranaka R, Kuroda M, Aoyagi Y, Nagashima T, Sangai T, Takada M, Nakagawa A, Kubota Y, Yokote K, Ohtsuka M. Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer. Breast Cancer Res Treat. 2020 Apr;180(3):625-634.
doi:10.1007/s10549-020-05581-x