千葉大学大学院医学研究院
耳鼻咽喉科・頭頸部腫瘍学
千葉大学病院
耳鼻咽喉・頭頸部外科
講師
2008年入局
千葉大学医学部附属病院 耳鼻咽喉・頭頸部外科
麻布高等学校、千葉大学医学部を卒業。
千葉大学大学院 医学薬学府 博士課程を経て
2018年 千葉大学大学院医学研究院 耳鼻咽喉科・頭頸部腫瘍学 助教
2025年 千葉大学医学部附属病院 耳鼻咽喉・頭頸部外科 講師
現在に至る
アレルギー学(特に花粉症や好酸球性副鼻腔炎)
がん免疫
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●Iinuma T, Okamoto Y, Yamamoto H, Inamine-Sasaki A, Ohki Y, Sakurai T, Funakoshi U, Yonekura S, Sakurai D, Hirahara K, Nakayama T. Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2015 Apr;114(4):289-98.
●Shinoda K, Hirahara K, Iinuma T, Ichikawa T, Suzuki AS, Sugaya K, Tumes DJ, Yamamoto H, Hara T, Tani-Ichi S, Ikuta K, Okamoto Y, Nakayama T. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2842-51.
●Iinuma T, Okamoto Y, Morimoto Y, Arai T, Sakurai T, Yonekura S, Sakurai D, Hirahara K, Nakayama T. Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy. 2018 Feb;73(2):479-489.
●Iinuma T, Yonekura S, Sakurai D, Inaba Y, Kawasaki Y, Okamoto Y. Investigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends. Allergol Int. 2020 Oct;69(4):616-618.
●Iinuma T, Kiuchi M, Hirahara K, Kurita J, Kokubo K, Yagyu H, Yoneda R, Arai T, Sonobe Y, Fukuyo M, Kaneda A, Yonekura S, Nakayama T, Okamoto Y, Hanazawa T. Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion. J Allergy Clin Immunol. 2022 Oct;150(4):850-860.e5.
●Iinuma T, Yonekura S, Hirahara K, Kurita J, Yoneda R, Arai T, Sonobe Y, Shinmi R, Okamoto Y, Hanazawa T. Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype. Allergol Int. 2023 Oct;72(4):564-572.
●Iinuma T, Kurokawa T, Aoki T, Onodera A, Fukazawa T, Yamada D, Kitahara G, Okoshi M, Yamaguchi M, Okura H, Sasaki S, Sasako Y, Kira S, Sharif J, Tsuchiyama Y, Kobayashi M, Kobayashi N, Horikoshi T, Inaba Y, Hanaoka H, Okamoto Y, Hanazawa T, Koseki H, Motohashi S. Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial. Nat Commun. 2025 Nov 26. doi: 10.1038/s41467-025-66801-w.
●Kiuchi M, Nemoto M, Yagyu H, Aoki A, Iwamura C, Sugimoto H, Masuo Y, Morita H, Ma S, Okuno Y, Hishiya T, Tsuji K, Sasaki A, Kokubo K, Ohishi K, Shinmi R, Sonobe Y, Iinuma T, Yonekura S, Yokomizo T, Komatsu N, Onodera A, Okumura S, Ito T, Hatano E, Tsuruyama T, Kurashima Y, Mato N, Suzuki T, Kimura MY, Motohashi S, Kawakami E, Ueno H, Tumes DJ, Hanazawa T, Nakayama T, Hirahara K. Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells. Science. 2025 Dec 11;390(6778):eadp0714. doi: 10.1126/science.adp0714.